Hydrogen gas inhibits lung cancer progression through targeting SMC3

In this study, researchers aimed to find a better way to treat lung cancer, a common and deadly form of cancer. Lung cancer is challenging to treat because it tends to spread to other parts of the body and can resist drugs. To do this, they looked at the effects of hydrogen gas (H2) on lung cancer cells in the lab and in mice.

Here’s what they did and what they found:

1. Lab Experiments: They used lung cancer cells and tested how H2 affected them in different ways. They looked at cell growth, cell death, cell movement, and the way cells divide.
2. Gene Investigation: They used advanced techniques to study the genes in the lung cancer cells. They found that a specific gene called SMC3 might be important in how lung cancer develops.
3. H2 Effects: They discovered that H2 had several positive effects:
   • It slowed down the growth of the cancer cells.
   • It made the cells less likely to move and spread.
   • It encouraged the cancer cells to die.
   • It caused the cells to get stuck in a particular phase of their growth.
4. Gene Changes: They found that H2 had a role in changing the activity of some genes, like SMC3, which is linked to the way chromosomes are organized during cell division.
5. Animal Tests: They also tested H2 on mice with lung cancer. The tumors in the mice that received H2 were smaller than in the control group, but not as small as the tumors in the group that got another cancer drug called cisplatin

Conclusion: The study showed that H2 can slow down the progress of lung cancer. It does this by affecting genes like SMC3, which plays a role in how cancer cells divide and grow. This research suggests that H2 might offer a new way to treat lung cancer, but more studies are needed to fully understand how it works.

Link to study is here : https://pubmed.ncbi.nlm.nih.gov/29852353/

The hydrogen system that was used in this study is similar to our HX3000 : https://hydrogen4health.com/hx3000-clinical-hydrogen-inhalation-system/