Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases
Toru Ishibashi, Miki Ichikawa, Bunpei Sato, Shinji Shibata, Yuichi Hara, Yuji Naritomi, Ken Okazaki, Yasuharu Nakashima, Yukihide Iwamoto, Samon Koyanagi, Hiroshi Hara, Tetsuhiko Nagao
Psoriasis, a chronic inflammatory skin disease, is caused by infiltrating lymphocytes and associated cytokines, including tumor necrosis factor (TNF)α, interleukin (IL)‑6, and IL‑17. Effective treatments, including pathogenesis‑based biological agents against psoriasis, are currently under development. Although the role of reactive oxygen species (ROS) in the pathogenesis of psoriasis has been investigated, it remains to be fully elucidated; ROS‑targeted therapeutic strategies are also lacking at present. Therefore, the objective of the present study was to assess whether H2, a ROS scavenger, has a therapeutic effect on psoriasis‑associated inflammation by reducing hydroxyl radicals or peroxynitrite in the immunogenic psoriasis cascade…
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