Oxidative stress is involved in the progression of Parkinson’s disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson’s features in model animals. In this a placebo-controlled, randomized, double-blind, parallel-group clinical pilot study, the authors assessed the efficacy of H₂ -water in Japanese patients with levodopa-medicated PD. Participants drank 1,000 mL/day of H₂-water or pseudo water for 48 weeks. Total Unified Parkinson’s Disease Rating Scale (UPDRS) scores in the H₂-water group (n=9) improved (median, -1.0; mean ± standard deviation, -5.7 ± 8.4), whereas UPDRS scores in the placebo group (n=8) worsened (median, 4.5; mean ± standard deviation, 4.1 ± 9.2). Despite the minimal number of patients and the short duration of the trial, the difference was significant (P<0.05). The results indicated that drinking H₂-water was safe and well tolerated, and a significant improvement in total UPDRS scores for patients in the H₂-water group was demonstrated... [/av_textblock] [av_button label='Read Full Article Here' link='manually,http://onlinelibrary.wiley.com/doi/10.1002/mds.25375/abstract;jsessionid=97ADCD97D3146C7FEEEEA015903E2541.f03t03' link_target='_blank' size='medium' position='right' icon_select='yes' icon='ue835' font='entypo-fontello' color='theme-color-highlight' custom_bg='#444444' custom_font='#ffffff' custom_class='' admin_preview_bg='' av_uid='av-2xcic0'] [/av_one_full]